INFLUENCE OF ONDANSETRON ON THERMOREGULATION DURING EXERCISE IN THE HEAT WEARING COMBAT CLOTHING

Authors
  1. McLellan, T.M.
  2. Ducharme, M.B.
  3. Bateman, W.A.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Ondansetron is a selective serotonin antagonist which has been shown to be an effective antiemetic agent for patients undergoing radiation or chemotherapy treatement. The Canadian Forces together with other NATO Countries have an interest in selecting an antiemetic agent that not only is effective in the prevention of emesis induced by chemical agents or radiation exposure, but also has minimal, if any, side effects. The prupose of this study was to examine the influence of a single 8-mg oral dose of the drug on thermoregulation during exercise in a hot (40C, 30% relative humidity) environment. Ten unacclimatized males performed a drug and placebo trial in a single-blind random order. The sessions involved walking on a treadmill at 4.8 km . h1(-) with a 2% elevation for a maximum of 3 h. Subjects wore combat clothing during the trials. Total exposure time was similar for the placebo (177 + or - 6 min) and drug (172 + or - 11 min) trials. Also, the rate of sweat production (0.64 + or - 0.1 and 0.66 + or - 0.1 kg . h1(-) for placebo and drug, respectively) and body heat gain (303 + or - 112 and 305 + or - 110 kJ for the placebo and drug, respectively) were not different between trials. Rectal temperature increased 1.48 + or - 0.40C for the placebo and 1.47 + or - 0.37C for the ondansetron trial. Finally, there was no difference in the mean skin temperature response which increased in both conditions to 37.1 + or - 0.5C. TRUNCATED
Keywords
Ondansetron
Report Number
DCIEM-92-49 — Reprint
Date of publication
31 Mar 1993
Number of Pages
6
Reprinted from
Aviat Space Environmental Medicine, vol 65, 1994, p 35-50
DSTKIM No
94-01869
CANDIS No
140245
Format(s):
Hardcopy;Originator's fiche received by DSIS

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