EFFICACY OF HLo-7 AND PYRIMIDOXIME AS ANTIDOTES OF NERVE AGENT POISONING IN MICE

Authors
  1. Clement, J.G.
  2. Hansen, A.S.
  3. Boulet, C.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The toxicity and efficacy of two oximes, HLo-7 and pyrimidoxime, were evaluated in mice and compared to those obtained with HI-6. HLo-7 and pyrimidoxime produced 24 h LD50 values of 356 and 291 mg/kg (i.p.), respectively. In combination with atropine (17.4 mg/kg, i.p.), HLo-7 was a very efficient therapy against poisoning by 3xLD50 dose of soman, sarin and GF and 2xLD50 dose of tabun with ED50 values of 12.4, 0.31, 0.32 and 25.2 mg/kg, respectively. In contrast, pyrimidoxime was a relatively poor therapy which resulted in ED50 values of >150,5.88,100 and 71 mg/kg against poisoning by soman, sarin, GF and tabun, respectively. HLo-7 produced significant (p<0.05) reactivation of phosphorylated acetylcholinesterase, in vivo, resulting in 47, 38, 27 and 10% reactivation of sarin, GF, soman and tabun inhibited mouse diaphragm acetylcholinesterase, respectively. HLo-7 also antagonized sarin-induced hypothermia in mice suggesting that it reactivated central acetylcholinesterase. The potential of HLo-7 as a replacement oxime for the treatment of nerve agent poisoning is discussed.
Date of publication
07 Oct 1991
Number of Pages
4
Reprinted from
Archives of Toxicology, vol 66, 1992, p 216-219
DSTKIM No
94-02450
CANDIS No
141310
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: