EXPERIMENTALLY INDUCED MORTALITY FOLLOWING REPEATED MEASUREMENT OF RECTAL TEMPERATURE IN MICE

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Soman (pinacolyl methylphosphonofluoridate) inhibits the enzyme acetylcholinesterase, which results in an increase in the concentration of the neurotransmitter acetylcholine and overstimulation of the cholinergic receptors. Cholinergic receptor downregulation following exposure to an increased concentration of neurotransmitter or agonist is a general phenomenon; however, in vitro receptor binding does not indicate the functional significance of the downregulation. Oxotremorine is a potent muscarinic cholinergic receptor agonist, which is active in the central nervous system and produces a transient, dose-dependent hypothermia following parenteral administration to mice. I attempted to use the temporal response to oxotremorine-induced hypothermia as an indicator of the in vivo functionality of the muscarinic receptor following soman poisoning. However, as reported here, experimentally induced mortality prevented this objective from being reached.
Date of publication
01 Aug 1993
Number of Pages
2
DSTKIM No
94-02656
CANDIS No
141316
Format(s):
Hardcopy;Originator's fiche received by DSIS

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