RECOVERY FROM SOMAN-INDUCED HYPOTHERMIA IS DUE TO AN INCREASE IN ACETYLCHOLINESTERASE ACTIVITY BUT NOT NEW PROTEIN SYNTHESIS

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Organophosphate-induced hypothermia in rodents appears to be due to stimulation of muscarinic receptors in the anterior hypothalamus. The nerve agent soman (pinacolyl methylphosphonofluoridate) produced a transient hypothermia in mice. Concomitant with the recovery from soman-induced hypothermia, which was complete within 6 hr, there was a parallel recovery of the hypothermia, which was complete within 6 hr, there was a parallel recovery of the hypothalamic acetylcholinesterase activity. Pretreatment of mice with the protein synthesis inhibitor, cycloheximide, did not affect the recovery from soman-induced hypothermia nor the recovery of hypothalamic acetylcholinesterase activity. The results suggest that the recovery from soman-induced hypothermia may be due to the recovery of acetycholinesterase, perhaps from the assembly of previously synthesized precursors.
Date of publication
28 Apr 1993
Number of Pages
6
Reprinted from
Neuro Toxicology, vol 14, no 4, 1993, p 411-416
DSTKIM No
94-02372
CANDIS No
141317
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: