CENTRAL ACTIVITY OF ACETYLCHOLINESTERASE OXIME REACTIVATORS

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The ability of various oximes to antagonize the sarin-induced hypothermia and reactivate phosphorylated acetylcholinesterase was used as an indicator of the central activity of oximes. HI-6, but neither toxogonin nor PAM C1, antagonized sarin-induced hypothermia and reactivated brain acetylcholinesterase, in particular hypothalamic acetylcholinesterase. The sarin-induced hypothermia appears to be a muscarinic chloinergic action since atropine was also an effective antagonist of sarin-induced hypothermia. Neither HI-6 nor toxogonin antagonized oxotremorine-induced hypothermia, indicating that these oximes do not possess central cholinolytic activity. The results demonstrated that HI-6 penetrated the blood-brain barrier in a sufficient concentration to produce a biochemical and physiological action against sarin poisoning.
Date of publication
20 Sep 1991
Number of Pages
8
Reprinted from
Toxicology and Applied Pharamacology, no 112, 1992, p 104-109
DSTKIM No
94-02482
CANDIS No
141319
Format(s):
Hardcopy;Originator's fiche received by DSIS

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