CHROMODACRYORRHEA IN RATS: ABSENCE FOLLOWING SOMAN POISONING

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Chromodacryorrhea (the shedding of so-called "bloody" tears") was apparent in rats very soon (within minutes) after the parenteral injection of the cholinergic agonist such as oxotremorine (J.G. Clement, unpublished observation) and acetylcholine (Tashiro et al., 1949). However, chromodacryorrhea was rarely observed following poisoning by lethal or sublethal does of either the potent organophosphate acetylcholinesterase inhibitor, soman (pinacolyl methylphosphonofluoridate; unpublished observations, J.G. Clement) or carbamate acetylcholinesterase inhibitors, such as physostigmine (Tashiro et al., 1940). The purpose of this investigation was to determine the pharmacological nature of this investigation was to determine the pharmacological nature of chromodacryorrhea in rats and the reason for the difference in response between direct-acting cholinergic agonists and the organophosphate acetylcholinesterase inhibitor, soman.
Date of publication
09 Aug 1993
Number of Pages
7
Reprinted from
Toxicology and Applied Pharmacology, vol 124, 1994, p 52-58
DSTKIM No
94-02371
CANDIS No
141321
Format(s):
Hardcopy;Originator's fiche received by DSIS

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