EFFICACY OF VARIOUS OXIMES AGAINST GF (CYCLOHEXYL METHYLPHOSPHONOFLUORIDATE) POISONING IN MICE

Authors
  1. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The efficacy of oxime (HI-6, toxogonin or PAM C1) therapy against GF (cyclohexyl methylphosphonofluoridate) poisoning was assessed in mice. It was found that the combination of atropine and either toxogonin or HI-6 were effective therapies against GF poisoning. PAM therapy was ineffectve. HI-6 was the only oxime which reactivated GF inhibited acetylcholinesterase. This might explain the reason why the HI-6 treated mice appeared to recover more quickly from the incapacitating effects folowing GF poisoning.
Date of publication
03 Sep 1991
Number of Pages
2
Reprinted from
Arch Toxicol, no 66, 1992, p 143-144
DSTKIM No
94-02483
CANDIS No
141322
Format(s):
Hardcopy;Originator's fiche received by DSIS

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