EFFICACY OF DIAZEPAM AND AVIZAFONE AGAINST SOMAN-INDUCED NEUROPATHOLOGY IN BRAIN OF RATS

Authors
  1. Clement, J.G.
  2. Broxup, B.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);BioResearch Labs Ltd, Montreal QUE (CAN)
Abstract
The purpose of this investigation was to compare the efficacy of diazepam and a water soluble pro-diazepam drug, avizafone (lysyl, peptido-aminobenzophenone diazepam pro-drug) in preventing or reducing the severity of soman-induced neuropathology in rats and to determine the temporal relationship between seizure initiation, anticonvulsant administration and the incidence and severity of soman-induced neuropathology. Brains from rats, treated with a convulsant dose of soman (pinacolyl methylphosphonofluoridate) and anticonvulsants such as diazepam and avizafone, were evaluated by light microscopy for evidence of neuropathology.
Date of publication
13 Jul 1993
Number of Pages
20
Reprinted from
NeuroToxicology, vol 14, no 4, 1993, p485-504
DSTKIM No
94-02501
CANDIS No
141323
Format(s):
Hardcopy;Originator's fiche received by DSIS

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