STAPHYLOCOCCAL ENTEROTOXINS AS SUPERANTIGENS

Authors
  1. Bhatti, A.R.
  2. Micusan, V.V.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Institut Armand Frappier, Laval QUE (CAN)
Abstract
Food poisoning associated staphylococcal enterotoxins and other bacterial products of diverse origin are now the subject of intense immunological research. These substances have special properties which determine their designation as superantigens. In combination with class II antigens of major histocompabibility complex the superantigens stimulate T cells bearing defined V beta or V gamma receptors. Thus, this group of substances influence the T cell activities by controlling their repertoire, their cytokines production and their modulation of the immune response. As a consequence, superantigens might be at the origin of bacterial and autoimmune diseases. In this review we focus on staphylococcal enterotoxins as representative members of the superantigen family and describe their proposed mechanism of action.
Report Number
DRES-M-1412 — Memorandum
Date of publication
01 Feb 1994
Number of Pages
39
DSTKIM No
94-02448
CANDIS No
141351
Format(s):
Hardcopy;Originator's fiche received by DSIS

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