STAPHYLOCOCCAL ENTEROTOXIN: ROLE OF INTESTINAL IMMUNITY IN ENTEROTOXIN B INTOXICATION

Authors
  1. Bhatti, A.R.
  2. Micusan, V.V.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Institut Armand Frappier, Laval QUE (CAN)
Abstract
To investigate the role of intestinal immunity in staphylococcal enterotoxins intoxication. We have chosen the mouse as experimental model, which although resistent to enterotoxins, has a certain advantage by not having an emetic mechanism, thus no loss in peroral administered enterotoxin takes place. Parenterla administration of enterotoxins induced a high titer of specific antibodies in serum, mainly of IgG and IgG2a subclasses. Peroral administration of enterotoxin elicited a good response at the intestinal level as showed by specific anti-enterotoxin antibodies in the supernatants of "in vitro" cultured intestinal fragments and the synthesized immunoglobulin was IgA. When different routes and combinations of them were studied it was observed that a parenteral followed by peroral administration opf enterotoxin induced the higher intestinal immune response. Secretion of specific antienterotoxin antibodies by intestinal immune system also lasted longer compared to the presence of antibodies in serum of perorally by immunized animals.
Keywords
Staphylococcus aureus;Staphylococcus enterotoxins;Enterotoxin B
Report Number
DRES-M-1390 — Memorandum
Date of publication
01 Feb 1994
Number of Pages
25
DSTKIM No
94-02823
CANDIS No
141445
Format(s):
Hardcopy;Originator's fiche received by DSIS

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