INTRAMYOCARDIAL CARBON DIOXIDE TENSION. A GUIDE TO THE SAFE PERIOD OF ANOXIC ARREST OF THE HEART

Authors
  1. MacGregor, D.C.
  2. Wilson, G.J.
  3. Holness, D.E.
  4. Lixfeld, W.
  5. Hisataka, D.V.M.
  6. and others
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The safe period of anoxic arrest of the heart is related to its individual metabolic activity rather than to a specific time interval. The capicity of the heart to produce energy through anaerobic metabolism, on which survival depends, has been assessed in this study by continuous monitoring of intramyocardial carbon dioxide tension (PCO2). Two groups of 12 dogs each were placed on total cardioplumonary bypass at 38C. and 28C., respectively. Anoxic arrest of the heart was produced by cross-clamping of the ascending aorta and venting of the left ventricle. Intramyocardial PCO2 was measured by a mass spectrometer, and carbon dioxide accumulation curves were plotted. An initial period during which the PCO2 increased in a linear fashion was followed by a period during which the rate of rise gradually until a plateau was reached. If the arrest was terminated at the transition point between these two periods, all hearts could be resucitated. If the arrest was terminated when the carbon dioxide.
Date of publication
01 Jul 1974
Number of Pages
7
DSTKIM No
94-04151
CANDIS No
142019
Format(s):
Hardcopy;Originator's fiche received by DSIS

Permanent link

Document 1 of 1

Date modified: