ISCHEMIC CONTRACTURE OF THE LEFT VENTRICLE: PRODUCTION AND PREVENTION

Authors
  1. MacGregor, D.C.
  2. Wilson, G.J.
  3. Tanaka, S.
  4. Holness, D.E.
  5. Lixfeld, W.
  6. and others
Corporate Authors
Toronto Univ, Toronto ONT (CAN) Banting Inst;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Ischemic contracture of the left ventricle ("stone heart") is a recognized complication of prolonged periods of interruption of the coronay circulation during open-heart surgery. We have examined the effects of moderate hypothermia (28C) and preoperative beta-adrenergic blockade (propranolol, 0.5 mg. per kilogram; 1.0 mg. per kilogram) on contracture development during ischemic arrest of the heart. Four groups of 8 dogs each were placed on total cardiopulmonay bypass, and ischemic arrest of the heart was produced by cross-clamping the ascending aorta and venting the left ventricle. Intramyocardial carbon dioxide tension was continuously monitored by mass spectrometry. When anaerobic energy production ceased, as indicated by a final plateau in the intramyocardial carbon dioxide accumulation curve, the ischemic arrest was terminated and the contractile state of the heart observed. These results are given in the test. We conclude that beta-adrenergic blockade delays, but does not prevent, the onset of ischemic contracture of the left ventricle under normothermic conditions. Moderate hypothermia appears to prevent this complication completely.
Date of publication
16 Apr 1975
Number of Pages
10
DSTKIM No
94-03142
CANDIS No
142020
Format(s):
Hardcopy;Originator's fiche received by DSIS

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