IDENTIFICATION OF NORADRENALINE IN VENOM FROM THE FUNNEL-WEB SPIDER HOLOLENA CURTA

Authors
  1. Frew, R.
  2. Hamilton, M.G.
  3. Lundy, P.M.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Identification of noradrenaline in venom from the funnel-web spider Hololena curta. Toxicon 32, 511-515, 1994. Venom from the funnel-web spider Hololena curta was added to the Krebs-Henseleit solution bathing isolated ring preparations of rat thoracic aorta, suspended in water-jacketed organ baths, for the purpose of tension recordings. Hololena curta venom at dilutions of 1:100,000 to 1:1000 caused a marked vasoconstriction, which was completely inhibited by the alpha 1 adrenoceptor antagonist prazosin (1 mu M). The vasoconstriction appears to be due to the direct effects on alpha 1 adrenoceptors of a venom constituent, which we have identified using HPLC/ECD as the catecholamine, noradrenaline.
Date of publication
31 Aug 1993
Number of Pages
5
Reprinted from
Toxicon, vol 32, no 4, 1994, p 511-515
DSTKIM No
94-03798
CANDIS No
143425
Format(s):
Hardcopy;Originator's fiche received by DSIS

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