STUDY OF THE ACCELERATED STORAGE AND STABILITY OF BIOLOGICAL DETECTORS

Authors
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);J D Biologicals Inc, Brampton ONT (CAN)
Abstract
During the past decade numerous advances have been made in analytical systems that employ biological molecules for detection. This particularly so for systems using antibody-based detection which have military applications in detection/identification of biological agents and in diagnosis of infectious diseases. The overall operation and function of detection systems is affected by the stability of the antibodies themselves. The purpose of this work was to examine the stability of a number of antibody preparations that had been lyophilized (freeze-dried) and/or reconstituted in aqueous buffer solution. Several buffer formulations were used in the antibody preparations. These preparations were stored at temperatures ranging from -20 to 60C and the residual antibody activity was determined at regular intervals. The stabilizing effects of the various buffer preparations were examined. This work was carried out in support of the development phase of the Biochemical Detector.
Report Number
DRES-CR-94-017 — Contractor Report
Date of publication
01 May 1994
Number of Pages
23
DSTKIM No
94-03757
CANDIS No
143444
Format(s):
Hardcopy;Originator's fiche received by DSIS

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