HISTOPATHOLOGIC STUDIES ON THE PROTECTIVE EFFECTS OF CHOLINOLYTICS FOLLOWING EXPOSURE TO SOMAN AND OTHER EXCITOTOXINS IN S-D RATS

Authors
  1. Tryphonas, L.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Nucro Technics, Scarborough ONT (CAN)
Abstract
The protective effect of aminophylline, AP-5 avizafone, CGS 18164A, diazepam, ketamine, lithium, (-)-MK-801, (+)-MK-801, and oxitremorine against soman (pinacolyl methylphosphonofluoridate) neurotoxicity and cardiotoxicity was evaluated in mature Sprague-Dawley (S-D) rats using histologic examination. The objective of the histopathologic examination was to determine the incidence and severity of soman-induced CNS and myocardial lesions in rats exposed to a single dose of soman 10 min after the administration of varying doses of these protective compounds. The rats were killed 72 h later. In separate experiments, the neurotoxic and cardiotoxic effects of kainic acid (12 and 24 mg/kg) and soman (60 and 40 mg/kg) were studied in S-D rats exposed to single doses of thees excitotoxins.
Report Number
DRES-CR-94-019 — Contractor Report
Date of publication
01 May 1994
Number of Pages
156
DSTKIM No
94-03768
CANDIS No
143449
Format(s):
Hardcopy;Originator's fiche received by DSIS

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