HISTOPATHOLOGIC EXAMINATION OF THE HEART OF RATS TREATED WITH SOMAN

Authors
  1. Tryphonas, L.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Nucro Technics, Scarborough ONT (CAN)
Abstract
As reported earlier, soman (pinacolyl methylphosphonofluoridate is a potent cholinesterase (ChE) inhibitor known to produce overt neurologic excitation and subsequent neuropathologic changes. Soman-induced clinical signs include salivation, diarrhea, lacrimation, tremors, convulsions, and seizures. In serious cases of poisoning, respiratory distress leading to death due to anoxia caused by respiratory paralysis may be encountered. In a recent study the sequence of events leading to brain and myocardial damage was defined (Tryphonas and Clement) and it was shown that soman-induced excitotoxic encephalopathy proceeds pari passu with degenerative cardiomyopathy. CNS lesions were found in the piriform cortex, amygdala, hippocampus, dorsal thalamus, and substantia nigra. Myocardial degeneration was localized in the left ventricular wall and progressed to replacement fibrosis. To characterize this brain-heart relationship further, hearts from rats treated with various combinations of atropine methylnitrate, HI-6, soman, diazepam, and avizafone were evaluated by light microscopy for evidence of cardiomyopathy. The purpose of the study was to define the protective effect of diazepam and avizafone administered at predetermined time points before and after soman dosing.
Report Number
DRES-CR-94-018 — Contract Report
Date of publication
01 Nov 1993
Number of Pages
88
DSTKIM No
94-03853
CANDIS No
143451
Format(s):
Hardcopy;Originator's fiche received by DSIS

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