EFFECT OF MODAFINIL ON HEAT PRODUCTION AND REGULATION OF BODY TEMPERATURES IN COLD-EXPOSED HUMANS

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Authors
  1. Bourdon, L.
  2. Jacobs, I.
  3. Bateman, W.A.
  4. Vallerand, A.L.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Military personnel often undergo sustained operations that affect vigilance and alertness. Pharmacological agents may be used to enhance vigilance. Most such agents also have thermogenic properties. Whether a new promising stimulant, modafinil (Lyons and French, Aviat. Space Environ. Med. 1991; 62:432-435), has a beneficial effect on cold tolerance in the military context, is not known. The goal of this study was, therefore, to evaluate the effect of this new drug on thermal balance and the regulation of body temperatures in neutral conditions and when challenged by a cold exposure. Nine subjects underwent three trials each: two in the cold (3 h at rest, 10C) 0.5 h after the ingestion of either placebo or modafinil (200 mg), and one in thermal neutrality with modafinil (same conditions except Tdb = 29.3C). As expected, cold produced a drop in Tre and Tsk and an increase in VO2. Although non-significant, there was tendency for a slightly greater drop in Tre with modafinil (0.65C vs. 0.57C with placebo). A similar tendency was found for the heat debt (S) which was greater with modafinil than with placebo (16.1 + or - 0.7 vs. 14.7 + or - 0.6 kJ.kg 1(-), respectively, +9.5%, p = 0.11). This tendency appears to be the combined result of slightly lower mean heat production during the test and a slightly greater mean dry heat loss. When tested at thermal neutrality, the drug had no effect on any thermal or metabolic parameters. TRUNCATED
Keywords
Modafinil;Stimulants
Report Number
DCIEM-93-51 — Reprint
Date of publication
01 Nov 1994
Number of Pages
6
Reprinted from
Aviation Space and Environmental Medicine, no 65, 1994, p 999-1004
DSTKIM No
95-00693
CANDIS No
148901
Format(s):
Hardcopy;Document Image stored on Optical Disk

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