THE USE OF VIRUS ATTACHMENT PROTEINS FOR THE TARGETING OF LIPOSOME ENCAPSULATED MATERIALS TO HOST CELLS

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Authors
  1. Lee, P.W.K.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Calgary Univ, Calgary ALTA (CAN) Dept of Microbiology and Infectious Diseases
Abstract
The objective of this study was to develop a protocol to isolate adequate amounts of sigma 1 protein which is responsible for the specific recognition and attachment of the virus to the host cell. The sigma 1 protein could be conjugated to the exterior of liposomes, to specifically deliver the contents of the liposome to a host target cell. Antibodies and other ligands had been used in the past for specific targeting of liposomes and other antibody conjugates. This was a novel method of the use of the cell attachment proteins to viruses to target delivery to host cells. The advantage of this method over other means, is that virus attachment proteins retain fusogenic activity, possibly allowing greater efficiency in delivery of the contents of the liposome inside the cell.
Keywords
Drug delivery
Report Number
DRES-CR-95-13 — Contract Report (Final)
Date of publication
01 May 1995
Number of Pages
15
DSTKIM No
95-04507
CANDIS No
151744
Format(s):
Document Image stored on Optical Disk;Hardcopy

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