LIPOSOMAL ALPHA-TOCOPHEROL ALLEVIATES THE PROGRESSION OF PARAQUAT-INDUCED LUNG DAMAGE

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Authors
  1. Suntres, Z.E.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Biochemistry
Abstract
The present study was carried out to investigate the efficacy of lipsome-associated alpha-tocopherol in treating pulmonary damage caused by paraquat exposure. Alpha-Tocopherol lipsomes (8mg alpha-tocopherol/kg body weight) or plain liposomes were intratacheally instilled into the lungs of rats 24 h after paraquat treatment (20 mg/kg,ip); treated animals were killed 8,24 or 48 h after administration of the liposomal preparations. Lungs of animals exposed to paraquat were extensively damaged as evidenced by an increase in lung weight and decreases in pulmonary angiotensin converting enzyme and alkaline phosphatase activities. Also, paraquat resulted in a significant reduction in glutathione (GSH) concentration in the lung and an elevation in microsomal lipid peroxidation levels, as measured by the formation of diene conjugates. Treatment of paraquat-injected rats with plain liposomes did not significantly alter paraquat-induced changes of all parameters examined. On the other hand, treatment of rats with alpha-tocopherol lipsomes, 24 h after paraquat administration, resulted in a significant increase in pulmonary alpha-tocopherol concentrations as well as a reduction in paraquat-induced changes in lipid peroxidation, GSH concentration, and lung angiotensin converting enzyme and alkaline phosphatase activities. TRUNCATED.
Keywords
Paraquat;Drug delivery;Lipid peroxidation;Oxidant-induced tissue damage
Report Number
DCIEM-94-P-38 — Reprint
Date of publication
01 Jan 1995
Number of Pages
8
Reprinted from
J of Drug Targeting, vol 2, 1995, p 493-500
DSTKIM No
95-02772
CANDIS No
151942
Format(s):
Document Image stored on Optical Disk;Hardcopy

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