PRACTICAL APPLICATIONS OF NEURONAL TISSUE CULTURE IN IN VITRO TOXICOLOGY

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Authors
  1. Sawyer, T.W.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
1. Primary chick embryo forebrain neurones are relatively easy to culture and are quite resilient to treatment manipulation. These characteristics have allowed application in a surprisingly diverse number of areas. 2. These cultures have been used to investigate the anti-cholinesterase potencies of many organophosphate (OP) nerve agents and insecticides. 3. These cultures have been userd to quantitate levels of OP in 'spiked' unknowns and in OP-contaminated soil samples. 4. These cells have also been used to test a variety of compounds using the MTT and neutral red cytotoxicity assays.
Keywords
Neuronal tissue;Neurotoxicity;Cell culture;Organophosphates;Neutral red cytotoxicity assays
Report Number
DRES-OL-94-29 — Reprint
Date of publication
12 Jul 1995
Number of Pages
2
Reprinted from
Clinical and Experimental Pharmacology and Physiology, vol 22, 1995, p 295-296
DSTKIM No
95-03606
CANDIS No
152707
Format(s):
Document Image stored on Optical Disk;Hardcopy

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