INTERACTIONS OF NORADRENERGIC, DOPAMINERGIC AND SEROTONINERGIC MECHANISMS ON COLD THERMOGENESIS AND CORE TEMPERATURE

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Authors
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Laval Univ, Quebec QUE (CAN) Dept of Physiology
Abstract
The present study was planned to investigate the mechanisms underlying the respective or interactive effects of dexfenfluramine and phentermine on metabolic rate and cold tolerance. A first series of experiments was carried out to determine the respective effects of various doses of phentermine and dexfenfluramine on oxygen consumption (VO2) and respiratory quotient (RQ). A second series of experiments was conducted to assess the respective and combined effects of various does of phentermine and dexfenfluramine on food intake, VO2 and RQ. A third series of experiments was carried out to determine the role of dopaminergic, serotoninergic and noradrenergic mechanisms in the effects of phentermine and dexfenfluramine on VO2 and RQ. A fourth series of experiments was aimed at studying cold tolerance in rats treated with various doses of phentermine and dexfenfluramine. A fifth series of experiments was planned to assess the effects of phentermine and dexfenfluramine on sympathetic nervous system (SNS) activity in rats kept at ambient temperature (24C) or exposed on cold (-5C). A sixth series of experiments was aimed at exploring the role of the dopaminergiv and serotoninergic mechanisms in the effects of phentermine and dexfenfluramine on cold tolerance.
Keywords
Phentermine;Dexfenfluramine
Date of publication
01 Feb 1995
Number of Pages
36
DSTKIM No
95-04334
CANDIS No
153013
Format(s):
Document Image stored on Optical Disk;Hardcopy

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