EFFECT OF TRIAZOLAM ON RESPONSES TO A COLD-WATER IMMERSION IN HUMANS

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Authors
  1. Bourdon, L.
  2. Jacobs, I.
  3. Bell, D.
  4. Ducharme, M.B.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Managing alertness of soldiers during sustained operations is a source of serious concern for military unit commanders. A frequently employed strategy is to induce sleep before an operation, especially operations requiring prolonged travel. Sleep-inducing drugs could have an action on thermoregulation through their effect on alertness and a possible direct effect on the brain. The goal of this study was therefore to evaluate the effect of a commonly prescribed triazolam (Halcion (TRADEMARK)) on thermoregulatory responses to cold-water immersion. Eight subjects were immersed twice in 18C water for up to 90 min in the morning; once after ingesting 0.25 mg triazolam (TRZ) the prior evening, and again after placebo (PLB) treatment. There were no significant differences between trials for mean duration of the immersion, the change in reactal temperature and mean skin temperature. Total metabolic heat production was similar for both conditions: 767 + or - 107 vs 781 + or - 105 kJ.m -(2) for TRZ and PLB, respectively. The results should be considere din light of large variation among the subjects in sensitivity to TRZ, which was unrelated to biometrical characteristics such as surface area-to-mass ratio, lean body mass, % body fat, and physical fitness. TRUNCATED
Keywords
Triazolam;Halcion
Report Number
DCIEM-94-42 — Reprint
Date of publication
31 Jul 1995
Number of Pages
5
Reprinted from
Aviation Space and Environmental Medicine, vol 66, no 7, 1995, p 651-655
DSTKIM No
96-00102
CANDIS No
154363
Format(s):
Document Image stored on Optical Disk;Hardcopy

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