Search for Radioprotective Compounds. Part XIII. SYNTHESIS AND PROTECTIVE ACTIVITY OF SOME S-(3-ALKYLAMINO-2-HYDROXYPROPYL) PHOSPHOROTHIOATES AND THIOSULFATES

Authors
  1. Grant, G.A.
  2. Shaw, K.B.
  3. Miller, R.K.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The effect on radiation protection in mice of the number of carbon atoms in the alkyl substituent on the amino-nitrogen atoms of S-(3-alkylamino-2-hydroxylpropyl) phosphorothioates and thiosulfates was investigated. The compounds were synthesized by reaction of an amine with epichlorohydrin to give a 1-alkylamino-3-chloro-2-propanol which was treated with trilithium phosphorothioate or ammonium thiosulfate to give the required compounds. In both series of compounds the toxicity increased as the number of carbon atoms in the alkyl chain increased. The toxicities ranged from greater than 1000 mg/kg for the parent compounds to 33 mg/kg for the n-decyl-substituted thiosulfate. In the phosphorothioate series the protection afforded to the bone marrow as assessed by LD sub 50/30 measurements decreased from dose reduction factors of 1.52 to approximately 1.12 with an increase in alkyl chain length up to 7 carbon atoms, and then increased to about 1.3 when an 8, 9 or 10 carbon chain was pr
Report Number
667 — Technical Report
Date of publication
15 Nov 1972
Number of Pages
43
DSTKIM No
73-00532
CANDIS No
16906
Format(s):
Hardcopy;Originator's fiche received by DSIS

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