Search for Radioprotective Compounds. Part XIV. SYNTHESIS AND PROTECTIVE ACTIVITY IN MICE OF METHYL (2-n-DECYLAMINO- ETHYLTHIO)- AND METHYL (S-2-(3-AMINOPROPYLAMINO)ETHYL- THIO)GLYCOLATES

Authors
  1. Grant, G.A.
  2. Sowa, W.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
Methyl (2-n-decylaminoethylthio)glycolate and methyl (S-2-(3-aminopropylamino)ethylthio)glycolate were synthesized by reacting the thiol hydrochlorides with methyl glyoxylate. The compounds were tested for radioprotective properties in mice in which seven- and thirty-day survival studies were done to assess the protection to the gut and bone marrow respectively. Methyl (S-2-(3-aminopropylamino)ethylthio)glycolate affords dose reduction factors (DRF's) of 1.63 for bone marrow and 1.46 for gut and a short duration of action of 15 to 30 min. Methyl (2-n-decylamino-ethylthio)glycolate provides DRF's of 1.44 for bone marrow and 1.18 for the gut and a duration of action of up to 60 min.
Report Number
669 —
Date of publication
15 Feb 1973
Number of Pages
21
DSTKIM No
73-02638
CANDIS No
18257
Format(s):
Hardcopy;Originator's fiche received by DSIS

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