SOME PRINCIPLES OF EVALUATING THE EFFICIENCY OF RADIOPROTECTIVE AGENTS IN MAN

Authors
  1. Vladimirov, V.G.
  2. Durakovic, A. (tr)
  3. Grant, G.A.
  4. and others
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The authors determined the protective dose of cystamine hydrochloride for man by extrapolating the optimal protective dose for mice with due consideration for the quantity of the protector per unit of body surface. It amounts to about 3 g. It is shown that the intake of tolerable doses of cystamine (0.8 - 1.2 g) prior to single local irradiation leads to a decrease in the number of chromosomal aberrations in myeloid cells and lymphocytes of the peripheral blood. A number of investigations enabled the authors to assess the prophylactic intake by man.
Report Number
TN-72-35 —
Date of publication
15 Feb 1973
Number of Pages
16
Translation of
Med Radiol, vol 16, 1971, p 54-60
DSTKIM No
73-02639
CANDIS No
18258
Format(s):
Hardcopy;Originator's fiche received by DSIS

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