EFFECT OF LITHIUM ON ACUTE OXYGEN TOXICITY AND ASSOCIATED CHANGES IN BRAIN GAMMA-AMINOBUTYRIC ACID

Authors
  1. Radomski, M.W.
  2. Watson, W.J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Lithium, which has been used in the treatment of certain hyperexcitable states in humans, was tested at various doses and pretreatment times for its effectiveness against the convulsions and lung damage induced by hyperbaric oxygen (OHP). Changes in brain a-aminobutyric acid (GABA) prior to the onset of OHP convulsions were also monitored. Lithium proved to be highly effective in inhibiting the development of OHP-induced convulsions and lung edema in rats. Lithium also prevented the decrease in brain GABA which invariably precedes convulsions in control animals. The evidence suggests that the anti-convulsive property of lithium in the animal exposed to OHP is related to its effects on central neuroinhibitory processes and on brain GABA metabolism.
Report Number
RP-885 — Research Paper
Date of publication
01 Jan 1973
Number of Pages
6
Reprinted from
Aerospace Medicine, vol 44, no 4, 1973, p387-392
DSTKIM No
73-05016
CANDIS No
19880
Format(s):
Hardcopy

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