THE INFLUENCE OF GAMMA-RADIATION ON THE STRUCTURE AND BIOLOGICAL ACTIVITY OF OXYTOCIN, A CYCLIC OLIGOPEPTIDE

Authors
  1. Purdie, J.W.
  2. Lynn, K.R.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN);National Research Council of Canada, Ottawa ONT (CAN)
Abstract
During irradiation in aqueous solution under various conditions, the biological activity of oxytocin was lost exponentially, and the following D37 doses were found: aerated, 270 krads; deaerated, 230 krads; N2O saturated, 170 krads; deaerated + butanol, 440 krads. Thus, the hydroxyl radical appeared to be the principal inactivating species. Hydrolysis and analysis of irradiated hormone showed that cystine and tyrosine were the main residues affected.
Report Number
13064 —
Date of publication
01 Jan 1973
Number of Pages
7
Reprinted from
Int J Radiat Biol, vol 23, no 6, 1973, p 583-589
DSTKIM No
73-06171
CANDIS No
20638
Format(s):
Hardcopy

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