EFFECT OF SMALL DOSES OF CLONAZEPAM UPON GD-INDUCED SEIZURE ACTIVITY AND CONVULSIONS

Authors
  1. Lipp, J.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Monkeys were exposed to GD (7-8 g/Kg). One group received clonazepam (0.15 mg/Kg) by intravenous injection at the onset of the GD-induced seizure activity and convulsions or two hours prior to exposure to GD. The second group followed the same procedure, but received 0.07 mg/Kg of clonazepam. Cerebral electrical activity was recorded on an electroencephalograph throughout the experiment. Both doses of clonazepam completely abolished the GD-induced convulsions, but did not completely suppress the seizure activity in all animals. Both doses of clonazepam prevented the onset of the GD-induced abnormalities when given two hours prior to exposure to GD. Possible sites of action are discussed.
Report Number
TN-334 —
Date of publication
15 Nov 1973
Number of Pages
14
DSTKIM No
74-00928
CANDIS No
21413
Format(s):
Hardcopy;Originator's fiche received by DSIS

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