INHERITANCE OF RESPONSIVENESS OF TOLERANT ANIMALS TO A CROSS-REACTING ANTIGEN

Authors
  1. St Rose, J.E.M.
  2. Cinader, B.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Medical Biophysics
Abstract
Random-bred rabbits were rendered tolerant to human serum albumin (HA) by neonatal injections. Starting at 44 days of age, the rabbits were injected i.v. with para-azobenzenesulfonic acid human albumin. Animals which made an antibody response (TCR-responders) were mated with each other, as were animals which failed to make an antibody response (TCR-nonresponders). TCR-nonresponsiveness was found to breed true after 3 generations of selective matings. TCR-responsiveness did not appear to be correlated with tolerance duration or with any of the allotypic specificities (A1,2,3,) controlled at the Aa locus. There were no C6-deficient animals among TCR-responders nor among TCR-nonresponders.
Report Number
RP-920 — Research Paper
Date of publication
01 Jan 1973
Number of Pages
9
Reprinted from
Immunological Communications, vol 2, no 3, 1973, p231-240
DSTKIM No
74-02251
CANDIS No
22223
Format(s):
Hardcopy

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