GENETIC CONTROL OF THE TENDENCY TO TOLERANCE CIRCUMVENTION

Authors
  1. St Rose, J.E.M.
  2. Cinader, B.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN)
Abstract
Random bred rabbits were injected with human serum albumin (HA) at birth to induce tolerance to HA. Tolerant animals were then immunized with a p-azobenzenesulfonic acid derivative of human albumin (HA-D31). A proportion of these animals, 42%, (27/64) responded with the production of antibody to HA-D31 (TCR-responders). Matings were carried out between TCR-responders and between TCR-nonresponders, and the offspring were subjected to the same procedures as their parents. Selective breeding of TCR-responders produced 70% (12/17) responders after two generations. Selective breeding of TCR-nonresponders produced only TCR-nonresponders after the third generation. Fourth generation offspring of TCR-nonresponders, which were not injected with HA at birth, produced an antibody response to HA-D31. TRUNCATED
Report Number
RP-906 — Research Paper
Date of publication
01 Jan 1973
Number of Pages
7
Reprinted from
European J of Immunology, vol 3, no 7, 1973, p 409-415
DSTKIM No
74-02290
CANDIS No
22257
Format(s):
Hardcopy

Permanent link

Document 1 of 1

Date modified: