A RATIONAL BASIS FOR ACCOUNTING FOR THE IMPACT OF CONCENTRATION ON TOXICOLOGICAL ASSESSMENT AND ESTIMATION OF INJURY RESULTING FROM THE RELEASE OF CHEMICAL AND BIOLOGICAL WARFARE AGENTS

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Authors
  1. Yee, E.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
A rational, consistent, and simple methodology for the estimation of the degree of injury or damage to exposed military personnel around a chemical or biological warfare (CBW) agent release is developed. The proposed hazard analysis methodology places particular emphasis on the following important factors: (1) recognition that the toxicity of rapidly acting inhaled toxic materials is usually highly nonlinear, and use of a nonlinear toxic load to quantify this effect; (2) recognition that realistic estimates for toxicological assessment must explicity account for the fluctuating concentration in a dispersing plume, and development of a simple model for incorporation of these effects into the ensemble-averaged (mean) nonlinear toxic load; (3) recognition of the importance of identifying the relevant time scale for the application (i.e., the time scale appropriate for the response of the human lungs); and, (4) recognition of the variability in the exposed population to a specific toxic load of material, and use of probit relationships to model this varying susceptibility. Example calculations performed using the proposed methodology demonstrated the importance of accounting for concentration fluctuations in the hazard assessment. TRUNCATED
Keywords
Probit relationships
Report Number
DRES-634 —
Date of publication
01 Jan 1996
Number of Pages
49
DSTKIM No
96-01705
CANDIS No
228805
Format(s):
Document Image stored on Optical Disk;Hardcopy

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