ELECTROSPRAY MASS SPECTRA OF THERAPEUTIC OXIMES: HI-6, HS-6, OBIDOXIME, 2-PAM, TMB-4 AND HLo-7

PDF

Authors
  1. D'Agostino, P.A.
  2. Provost, L.R.
  3. Hancock, J.R.
  4. Boulet, C.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Pyridinium and bis-pyridinium oxime salts are currently in use or under development for treatment of patients exposed to organophosphorus nerve agents. The limited volatility and thermal liability of these compounds limits the number of mass spectrometric approaches that may be used to characterize these important compounds. Electrospray mass spectrometry, a relatively new ionization approach, was investigated as a possible technique for the identification of these oximes and their degradation products. Six therapeutic oxime salts, the bis-pyridinium oximes, HI-6, HS-6, Obidoxime, TMB-4 and HLo-7, and the pyridinium oxime, 2-PAM, were analyzed (CAD) opportunities afforded by the ESI interface. The CAD/ MS (MS^2) spectra of each oxime were acquired under two different sampling cone voltage settings and the usefulness of the second (quadrupole) mass analyzer associated with a hybrid tandem mass spectrometer was demonstrated for MS/MS and CAD/MS/MS (MS^3) applications including the reliable differentiation of similar bis-pyridinium oximes and the identification of a suspected HI-6 decomposition product.
Keywords
Obidoxime;HS-6;TMB-4;Chemical identification
Report Number
DRES-M-1475 — Memorandum
Date of publication
01 Dec 1995
Number of Pages
18
DSTKIM No
96-02377
CANDIS No
228806
Format(s):
Document Image stored on Optical Disk;Hardcopy

Permanent link

Document 1 of 1

Date modified: