SERUM CREATINE PHOSPHOKINASE LEVELS IN RATS FOLLOWING COLD INJURY

Authors
  1. Myles, W.S.
  2. Brown, T.E.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The validity of serum creatine phosphokinase (CPK) as an index of tissue damage due to cold injury was tested in the rat. Immersion of the feet in the freezing mixture (salt and ice, -19o ~ 1oC) for one or five minutes produced reversible and irreversible damage, respectively. The increase in CPK activity over a 5-hr period following freezing showed that the severity and extent of cold injury was associated with the amount of CPK released into the bloodstream. Exposure of the whole rat to cold air at -29oC for three hours resulted in a highly variable increase in serum CPK two hours after exposure which was related to the degree of hypothermia during the exposure. The extent of hypothermia was also related to the amount of tissue loss estimated two weeks after the exposure.
Report Number
RP-913 — Research Paper
Date of publication
01 Jan 1973
Number of Pages
8
Reprinted from
Int. J Biometeor, vol 17, no 2, 1973, p 177-184
DSTKIM No
74-03310
CANDIS No
22926
Format(s):
Hardcopy

Permanent link

Document 1 of 1

Date modified: