EFFECT OF BENZODIAZEPINE DERIVATIVES ON SOMAN-INDUCED SEIZURE ACTIVITY AND CONVULSIONS IN THE MONKEY

Authors
  1. Lipp, J.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The effect of clonazepam and nitrazepam upon soman-induced seizure activity and convulsions was studied in the monkey. Intravenous administration of either of these drugs, after the onset of the activity, effectively terminated the convulsions and suppressed the seizure activity. Administration of diazepam, clonazepam or nitrazepam prior to exposure of soman prevented the onset of seizure activity and convulsions with clonazepam and nitrazepam having the longest effective duration.
Report Number
TP-399 —
Date of publication
01 Jan 1973
Number of Pages
8
Reprinted from
Archives Internationales de Pharmacodynamie de Th rapie, vol 202, no 2, 1973, p 244-251
DSTKIM No
75-00189
CANDIS No
24183
Format(s):
Hardcopy

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