THE CHOLINESTERASE-INHIBITORY CHARACTERISTICS OF PARPANIT AND ITS ANALOGUES IN RELATION TO THEIR PROTECTIVE EFFECTIVENESS IN THE TREATMENT OF SARIN-POISONED RODENTS

Authors
  1. Bannard, R.A.B.
  2. Helie, J.G.
  3. Price, J.E..
  4. and others
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
Fifteen basic esters of 1-phenylcycloalkanecarboxylic acids were examined as reversible inhibitors of bovine erythrocyte acetylcholinesterase. All the compounds showed weak competitive or mixed inhibitory potencies of the compounds and the protection which they afforded to sarin-poisoned rodents when administered together with 1-methylpyridinium-2-aldoxime methanesulfonate.
Keywords
Sarin
Report Number
R595 —
Date of publication
15 Jul 1969
Number of Pages
4
Reprinted from
Vol 47. No. 12. p.1035-1038. 1969. Can Jof Physiology and Pharmacology.
DSTKIM No
70-01182
CANDIS No
2655
Format(s):
Hardcopy;Originator's fiche received by DSIS

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