COMPARISON OF THE EFFICACY OF HS-6 VERSUS HI-6 WHEN COMBINED WITH ATROPINE, PYRIDOSTIGMINE AND CLONAZEPAM FOR SOMAN POISONING IN THE MONKEY

Authors
  1. Lipp, J.
  2. Dola, T.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Monkeys were exposed to varying doses of soman and given therapy. Therapy consisted of pyridostigmine, clonazepam, atropine and HS-6 or HI-6. Cerebral electrical activity, heart rate, respiration, systemic blood pressure and cholinesterase activity were recorded throughtout the experiment. Administration of therapy immediately suppressed all seizure activity and convulsions and the animals appeared awake throughout the experiment. All animals exhibited bradycardia and hypotension following the administration of therapy.
Report Number
TP-519 —
Date of publication
01 Jan 1980
Number of Pages
11
Reprinted from
Archives Internationales de Pharmacodynamie et de Therapie, vol 246, no 1, 1980, p 138-148
DSTKIM No
81-00529
CANDIS No
31672
Format(s):
Hardcopy;Originator's fiche received by DSIS

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