MINIMAL EFFECTIVE DOSE OF HI-6 WHEN COMBINED WITH ATROPINE, CLONAZEPAM AND PYRIDOSTIGMINE FOR GD POISONING IN THE MONKEY

Authors
  1. Lipp, J.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Monkeys with chronic implanted cerebral electrodes were exposed to GD (60 mu g/kg) and treated with a combination of drugs which consisted of pyridostigmine, clonazepam, atropine, and HI-6. The dose of HI-6 varied, with three monkeys receiving 3.0 mg/kg and three receiving 7.5 mg/kg of HI-6. The EEG, heart rate, respiratory activity and blood pressure were recorded. The drugs were administered by intravenous (i.v.) injection at the onset of the GD-induced seizure activity and convulsions. All animals that received therapy containing 7.5 mg/kg of HI-6 survived. The therapy immediately suppressed the seizure activity and convulsions and the animals appeared quiet but awake. Two of the three animals that received 3.0 mg/kg of HI-6 survived. These animals appeared similar to the ones that received 7.5 mg/kg of HI-6, except that the heart rate, which exhibited an initial decrease, returned to the control level.
Report Number
294 —
Date of publication
15 Mar 1981
Number of Pages
10
DSTKIM No
81-02132
CANDIS No
33084
Format(s):
Hardcopy;Originator's fiche received by DSIS

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