THE ADHERENCE OF NEISSERIA MENINGITIDIS AND NEISSERIA GONORRHOEAE TO HUMAN EMBRYONIC KIDNEY CELLS

Authors
  1. White, L.A.
  2. Holbein, B.E.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The in vitro adherence of N. meningitidis isolates and N. gonorrhoeae colonial types to human embryonic kidney (HEK) cells was examined. Two of five serogroup B nasopharyngeal N. meningitidis isolates of different serotypes adhered to HEK cells, after one subculture from their initial isolation. All of the isolates possessed substantial numbers of pili after one subculture, and these results suggest that pili are not the sole mediators of adherence of N. meningitidis to HEK cells. Both pili and the ability of adhere were lost during seven subculturings. N. gonorrhoeae colonial type T cells were found to readily adhere to HEK cells and to be heavily piliated. Non piliated N. gonorrhoeae colonial type T4 cells were incapable of adherence to HEK cells.
Report Number
307 —
Date of publication
15 Aug 1981
Number of Pages
16
DSTKIM No
82-00127
CANDIS No
34846
Format(s):
Hardcopy;Originator's fiche received by DSIS

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