SERUM AND TISSUE DISTRIBUTION OF IRON FOLLOWING INTRAPERITONEAL INJECTION OF MICE WTH IRON DEXTRAN

Authors
  1. Holbein, B.E.
  2. Likes, G.C.
  3. Jericho, K.W.F.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The serum and tissue distribution of iron in mice was examined following intraperitoneal injection of 15 mg Fe per kg or 250 mg Fe per kg as iron dextran. Iron gained immediate access to serum with peak levels occurring 2.5 hr after injection. Iron entered the transferrin iron pool readily and saturated this pool within five hours. Total serum iron and transferrin-associated iron returned to normal values by 36 hr, at which time high levels of iron could be detected in the liver and spleen. Stored iron could not be detected histochemically in animals receiving 15 mg Fe per kg but abundant hemosiderin was still present at 72 hr post-injection in animals receiving 250 mg Fe per kg.
Report Number
305 —
Date of publication
15 Oct 1981
Number of Pages
13
DSTKIM No
82-00128
CANDIS No
34847
Format(s):
Hardcopy;Originator's fiche received by DSIS

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