ROLES OF IRON IN PATHOGENESIS BY NEISSERIA MENINGITIDIS IN MICE

Authors
  1. Holbein, B.E.
  2. Likes, G.C.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Strain M1011, a virulent strain of N. meningitidis, produced bacteremia and symptoms of infection when injected into mice without exogenous iron dextran. Mice rapidly responded to this infection and by 12 hours post-injection there was virtually no detectable plasma iron. Bacteria could not be recovered from the blood at 18 hours post-injection. Iron dextran enhanced bacteremia at dosages above 15 mg Fe per kg. However, fatal infection required a high dosage of iron dextran. Strain DRES-03, an avirulent strain, did not produce bacteremia even in mice given 250 mg FE per kg. Crude extracellular endotoxin from strain M1011 was found to be much more toxic for mice given 250 mg Fe per kg iron dextran than for mice receiving no iron. The results implicate two major roles for exogenous iron in pathogenesis. TRUNCATED
Report Number
304 —
Date of publication
15 Oct 1981
Number of Pages
14
DSTKIM No
82-00129
CANDIS No
34848
Format(s):
Hardcopy;Originator's fiche received by DSIS

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