RESPIRATORY DEPRESSION PRODUCED BY DIAZEPAM IN CATS: EFFECT OF ANAESTHESIA

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Authors
  1. Lee, M.J.
  2. Clement, J.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Diazepam (Valium, Roche; 0.37 mg/kg) was given by slow injection into the left femoral vein and flushed in with 0.9% saline. Within 3 min following the i.v. injection of diazepam spontaneous respiration ceased in cats anaesthetized with chloralose; mean arterial pressure fell from a control level of 99.4 (+ or - 28.03) mmHg to 32.5 (+ or - 13.44) mmHg. If artificial ventilation was initiated immediately upon cessation of respiration, the animal recovered. Cats anaesthetized with ketamine (Ketaset, Rogar; 44 mg/kg i.m.) showed no respiratory depression following i.v. diazepam injection.
Report Number
DRES-287 —
Date of publication
01 Jan 1980
Number of Pages
5
Reprinted from
Archives Internationales de Pharmacodynamie et de Therapie, vol 248, no 2, 1980, p 289-293
DSTKIM No
82-02665
CANDIS No
37044
Format(s):
Hardcopy;Originator's fiche received by DSIS;Document Image stored on Optical Disk

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