DETECTION OF DIAZEPAM AND DETERMINATION OF TIME OF INGESTION

Authors
  1. McBurney, L.J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Levels of diazepam metabolites excreted in the urine of eight male subjects were measured for several weeks after ingestion of a single therapeutic dose of 10 mg. Analyses were carried out using gas chromatography-mass spectrometric (GC/MS) procedures. Ratios of oxazepam to desmethyldiazepam and oxazepam to temazepam below 1.0 and 0.7, respectively, were characteristic of consumption within the previous 24 hours. Estimations of dosage and time since ingestion were made on samples from four individuals who had ingested 5 mg diazepam by comparing urinary metabolite concentrations and ratios to the control group data.
Report Number
RP-80-P-33 —
Date of publication
01 Jan 1981
Number of Pages
13
Reprinted from
Can Soc Forens Sci J, vol 14, no 4, 1981, p 152-164
DSTKIM No
82-02943
CANDIS No
37317
Format(s):
Hardcopy;Originator's fiche received by DSIS

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