MODAFINIL, D-AMPHETAMINE AND PLACEBO DURING 64 HOURS OF SUSTAINED MENTAL WORK I: EFFECTS ON MOOD, FATIGUE, COGNITIVE PERFORMANCE AND BODY TEMPERATURE

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Authors
  1. Pigeau, R.
  2. Naitoh, P.
  3. Buguet, A.
  4. McCann, C.
  5. Baranski, J.
  6. and others
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Forty-one military subjects received either 300 mg of modafinil, 20 mg of d-amphetamine, or placebo on 3 separate occasions during 64 hours of continuous cognitive work and sleep loss. Three drug treatments were given: at 23.30 hours and 05.30 hours during the first and second SD nights, respectively, and once at 15.30 hours during the third day of continuous work. Subjective estimates of mood, fatigue and sleepiness, as well as objective measures of reaction time, logical reasoning and short-term memory clearly showed better performance with both modafinil and amphetamine relative to placebo. Both modafinil and amphetamine maintained or increased body temperature compared to the natural circadian cycle observed in the placebo group. Also, from subject debriefs at the end of the study, modafinil elicited fewer side-effects than amphetamine, although more than the placebo group. Modafinil appears to be a good alternative to amphetamine for counteracting the debilitating mood and cognitive effects of sleep loss during sustained operations.
Keywords
Modafinil
Report Number
DCIEM-95-07 — Reprint
Date of publication
01 Jan 1995
Number of Pages
17
Reprinted from
J Sleep Res, vol 4, 1995, p 212-228
DSTKIM No
96-02025
CANDIS No
389688
Format(s):
Document Image stored on Optical Disk;Hardcopy

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