AN IN VITRO METHOD FOR THE SCREENING OF TRICHOTHECENE MYCOTOXIN CYTOTOXICITY AND THE STUDY OF MYCOTOXIN COUNTERMEASURES

Authors
  1. DiNinno, V.L.
  2. Penman, D.
  3. Bhatti, A.R.
  4. Erhardt, N.P.
  5. Lockwood, P.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
A thymocytic cell bio-assay was developed for assessing the toxicity of the trichothecene mycotoxin T-2. The in vitro toxicity of mycotoxin T-2 towards mouse mono-nuclear leukocytes prepared from spleen, thymus, peritoneal lavage and bone marrow cells was studied. Bone marrow cells were found to be be more resistant to T-2 toxicity than thymus, spleen and peritoneal cell preparations. This method is rapid and provides consistant and reproducible results for the study of T-2 mycotoxicosis.
Report Number
M-1147 —
Date of publication
15 Mar 1985
Number of Pages
12
DSTKIM No
85-01479
CANDIS No
46291
Format(s):
Hardcopy;Originator's fiche received by DSIS

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