A STUDY TO IMPROVE COLD TOLERANCE THROUGH THE ADMINISTRATION OF AMINOPHYLLINE

Authors
  1. Wang, L.C.
  2. Belcastro, A.N.
  3. Man, P.S.
Corporate Authors
Alberta Univ, Edmonton ALTA (CAN);Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The studies examined whether the combination of aminophylline and substrate feeding can improve cold tolerance and prevent the onset of hypothermia in severe cold. Semi-nude male subjects (n=14) either sat passively or exercised intermittently for 3 h at an individually adjusted ambient temperature which induced mild hypothermia. The procedure was repeated on several occasions with different combinations of either placebo or aminophylline combined with either water or a nutritional substrate. The results indicated that the combination of aminophylline and substrate significantly improved cold tolerance by slowing the rate of decrease of rectal temperature. The effect of aminophylline was most marked during exercise in the cold. The results suggest that the beneficial effect of aminophylline in this regard is mediated by enhanced substrate mobilization.
Date of publication
15 May 1985
Number of Pages
122
DSTKIM No
85-02200
CANDIS No
47002
Format(s):
Hardcopy;Originator's fiche received by DSIS

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