Mediators Affecting IL2 Function in Burn Immunosuppression

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Authors
  1. Sparkes, B.G.
  2. Teodorczyk-Injeyan, J.A.
  3. Peters, W.J.
  4. Falk, R.E.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Surgery;Wellesley Hospital, Toronto ONT (CAN) Ross Tilley Burn Centre
Abstract
Some laboratories have recently focused on the failure of IL-2 function in T lymphocytes of severely burned patients. Since it is known that PGE inhibits the production of human IL2, the authors tested the sensitivity of lymphocytes from the burn patients to induction of receptors for IL2, in the presence of indomethacin. At the time of the patients' immunosuppression (days 10 to 40), the decreased percentage of IL2R-bearing cells was not augmented by IM. On the first day, however, IM did augment the percentage of IL2R-positive cells. This indicated that endogenous PG production in PBMC was active on the first day but not at the time of immunosuppression. A biphasic release of eicosanoid metabolites in burn patients was reported to be very high on day 1 and was then exhausted. Our findings are consistent with this pattern.
Report Number
DCIEM-86-P-45 — Research Paper; Released for inclusion in Proceedings of NATO Advanced Research Workshop on Lipid Mediators in Immunology of Burn and Sepsis, Plenum Press, NY, 1987
Date of publication
01 Jan 1986
Number of Pages
18
DSTKIM No
87-00154
CANDIS No
49006
Format(s):
Document Image stored on Optical Disk;Originator's fiche received by DSIS

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