RADIOIMMUNOASSAY MEASUREMENT OF SENSITIVITY AND COMPLEMENT METABOLITE CHANGES IN DIVERS

Authors
  1. Ward, C.A.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Mechanical Engineering
Abstract
The consequences of complement activation and the symptoms of decompression sickness are similar. Consequently, the relation between the sensitivity of individuals to complement activation by air bubbles and their susceptibility to decompression sickness has been examined. Plasma samples from 34 individuals were incubated with air bubbles and the concentration of the fluid phase metabolites of complement activation C3a, C4a and C5a were measured with radioimmunoassays. It was found that both the anaphylatoxins C3a and C5a were produced by the presence of air bubbles but that the anaphylatoxin C4a was not. This finding indicates that air bubbles activate the complement system by the alternate pathway. One group of individuals was found to be particularly sensitive to complement activation by this pathway. They produced 3.3 times more C3a and 5.3 times more C5a in their plasma samples incubated with air bubbles as did the other group.
Date of publication
15 Aug 1986
Number of Pages
29
DSTKIM No
87-00570
CANDIS No
49421
Format(s):
Hardcopy;Originator's fiche received by DSIS

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