A NON-LINEAR DOSE-RESPONSE MODEL WITH AN APPLICATION TO THE RECONSTRUCTION OF THE HUMAN MORTALITY RESPONSE SURFACE FROM ACUTE INHALATION TOXICITY WITH SARIN

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Authors
  1. Yee, E.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The use of a non-linear toxic load in conjunction with the probit method for the characterization of the time-concentration-mortality relationship of a toxic gas is described. The basic principles underlying the extrapolation of the time-concentration-mortality relationships from animal to humans are examined. These methods are illustrated with reference to the re-evaluation of the raw data from a previously published study of a large-scale experiment on the acute inhalation toxicity of sarin (GB). For the four animal species (e.g.,rats, mice, guinea pigs, and pigeons) used in this study, the parameters in the probit relationship (including the toxic load exponent) have been derived using a maximum likelihood method based on the binomial distribution. From these results, a human acute inhalation toxicity model for GB intoxication is developed. This model can then be used to provide an estimate for the LC01, LC05, and LC50 values for humans as a function of the exposure time.
Keywords
Inhalation;Hazard assessment
Report Number
DRES-M-1476 — Memorandum
Date of publication
01 Apr 1996
Number of Pages
25
DSTKIM No
96-02393
CANDIS No
498477
Format(s):
Document Image stored on Optical Disk;Hardcopy

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