INTRATRACHEALLY ADMINISTERED LIPOSOMAL ALPHA-TOCOPHEROL PROTECTS THE LUNG AGAINST LONG-TERM TOXIC EFFECTS OF PARAQUAT

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Authors
  1. Suntres, Z.E.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The present study was carried out to investigate whether the antioxidant alpha-tocopherol, incorporated into liposomes and delivered directly to the lung, could protect the organ against the long-term toxic effects of paraquat. Plain liposomes (composed of dipalmitoylphosphatidylcholine, DPPC) or alpha-tocopherol liposomes were administered intratracheally to animals 24 h prior to an intrperitoneal injection of paraquat dichloride and rats were killed at different times after paraquat treatment. Results of this study showed that lungs of animals treated with paraquat were extensively damaged, as evidenced by significant increases in lung weight and decreases in lung angiotensin converting enzyme (ACE) and alkaline phosphatase enzyme (AKP) activities. Also, paraquat treatment resulted in increases in lipid peroxidation, suggesting that oxidant stress mechanisms may play an important role in paraquat-induced lung injury. Moreover, paraquat treatment resulted in a significant reduction in the number of neutrophils in the blood of rats with a concurrent increase in the pulmonary myeloperoxidase activity, suggestive of neutrophil infiltration in the lung of treated animals. Pretreatment of rats with liposomes alone did not significantly alter the paraquat-induced changes of all parameters examined. TRUNCATED
Keywords
Paraquat;Oxidant-induced tissue damage;Drug delivery;Inhalation therapy
Report Number
DCIEM-94-37 — Reprint
Date of publication
01 Dec 1995
Number of Pages
12
Reprinted from
Biomedical and Environmental Sciences, vol 8, 1995, p 289-300
DSTKIM No
96-02591
CANDIS No
498765
Format(s):
Document Image stored on Optical Disk;Hardcopy

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