STRENUOUS EXERCISE AND IMMUNOLOGICAL CHANGES: A MULTIPLE-TIME-POINT ANALYSIS OF THE LEUKOCYTE SUBSETS, CD4/CD8 RATIO, IMMUNOGLOBULIN PRODUCTION AND NK CELL RESPONSE

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Authors
  1. Shek, P.N.
  2. Sabiston, B.H.
  3. Buguet, A.
  4. Radomski, M.W.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The study was designed to examine the impact of exhaustive endurance exercise on a number of immune parameters of physically fit male subjects (VO2max 66.5 + or - 5.3 ml/min/kg) who performed treadmill exercise at 65% of their VO2max for 120 min. Serial blood samples were taken before, during and after exericse and changes in leukocyte and lymphocyte subset concentrations; immunoglobulin production in vitro; and natural killer (NK) cell response were measured. The exercise regimen was found to induce the well-known phenomenon of leukocytosis which consisted primarily of a granulocytosis and lymphocytosis. Among the lymphocyte subsets, peripheral pan T cells (CD3') as well as helper (CD4') and suppressor (CD8') T cells were found to be elevated. A relatively smaller increase in CD4' than CD8' cells resulted in depressed CD4/CD8 ratios throughout the exercise period.
Keywords
B cells;Immunoglobin;T cells;CD4/CD8 ratio
Report Number
DCIEM-94-P-22 — Reprint
Date of publication
01 Jan 1995
Number of Pages
10
Reprinted from
Int Sports Med, vol 16, no 7 1995, p 466-474
DSTKIM No
96-02280
CANDIS No
498766
Format(s):
Document Image stored on Optical Disk;Hardcopy

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